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Objectives To study the expression Prohibitin in proliferation vascular smooth muscle cells (VSMCs) after balloon injure in rat carotid artery.Methods Twenty-four male SD rats of SPF grade were randomly divided into control groups with 6 animals and injured group with 18 animals.Based on the model of balloon injure in rat carotid artery, the artery tissues were harvested on 7, 14, 28 days after operation.