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  5. ROS-sensing TRPM2 channel: a druggable therapeutic target?

ROS-sensing TRPM2 channel: a druggable therapeutic target?

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：feixiang20090911
【摘 要】
：
TRPM2 is a melastatin-related member of the transient receptor potential protein super-family and forms tetrameric Ca2+-permeable cationic channels that open upon binding of intracellular ADP-ribose a
【作 者】
：
Lin-Hua Jiang 
【机 构】
：
School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK
【出 处】
：
The 4th International Ion Channel Conference(第四届国际离子通道会议)
【发表日期】
：
2013年2期
【关键词】
：
TRPM2 ion channel Reactive oxygen species novel TRPM2 inhibitors 
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TRPM2 is a melastatin-related member of the transient receptor potential protein super-family and forms tetrameric Ca2+-permeable cationic channels that open upon binding of intracellular ADP-ribose and structurally related compounds.TRPM2 channels are also potently activated by reactive oxygen species (ROS), thus acting as a cellular sensor for ROS.
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