目的 肺癌胸腔积液尚缺乏系统的临床研究,本试验旨在分析肺癌相关性胸腔积液的患病率、病因、自然病程和其对生存期的影响.方法 连续纳入2008～2015年在我院新诊断的肺癌患者6895例,回顾性分析其临床病历和影像学资料.结果 患者中有4996例非小细胞肺癌,1346例小细胞肺癌.2827例(41％)肺癌患者病程中出现了胸腔积液,其中1690例(60％)的患者因胸腔积液过少无法抽取,这些积液未进展不需
目的 通过iNOS基因敲除小鼠观察iNOS信号通路在肺鳞状细胞癌发生发展过程中的重要作用,探讨iNOS在人肺鳞状细胞癌中治疗意义.方法 杂交L-IKKαK44A/K44A小鼠与L-IKKαK44A/K44ANOS2-/-小鼠为研究对象,通过PCR,qPCR,免疫印迹杂交,流式细胞学,HE染色,免疫荧光染色等方法 ,检测小鼠肺脏,脾脏内巨噬细胞的数量的变化,检测Trim29,Cox2等表达的变化,检
目的 Gastric aspiration lung injury is one of the most common clinical events associated with acute lung injury.This studyassessed the effects of bone marrow-derived mesenchymal stem cells(BMSCs)to gast
目的 研究IL-37对肺癌细胞增殖的抑制作用并探讨其可能机制.方法 通过Adv-IL-37转染LLC细胞,Elisa和Western检测转染后的LLC细胞IL-37表达情况.检测转染后LLC细胞的增殖能力、细胞周期及凋亡情况.建立IL-37对于小鼠和裸鼠肺癌治疗模型,评价IL-37对小鼠及裸鼠Lewis肺癌的冶疗效果.体外实验研究外源性IL-37对CD4+T细胞和CD8+T细胞活化及增殖的影响.结
目的 检测自噬相关蛋白Beclin1及p62在非小细胞肺癌中的表达，探讨它们与肺癌患者临床特征的关系.方法 1.蛋白印迹技术及免疫荧光染色法检测Beclin1及p62蛋白在A549、H1299、HCC827中的表达情况；2.免疫组织化学染色法检测肺癌组织芯片中Beclin1及p62蛋白的表达和分布.结果 1.Beclin-1及p62蛋白在A549、H1299及HCC827细胞株中均有表达.2.肺癌
目的 Tumor cells rely on aerobic glycolysis to generate ATP,namely the "Warburg" effect.2-deoxyglucose(2-DG)is wellcharacterized as a glycolytic inhibitor,but its effect on cellular signaling pathways h
目的 Needle biopsy of parietal pleura has become a very important diagnostic skill for clinicians.Does the diagnostic rate andsafety of pleura biopsy change over time？ Does the clinician need more train
目的 This study was designed to determine the effect of chronic sensitization with ovalbumin (Ova) on cough sensitivity to inhaled irritant gases in mice.方法 Conscious mice move freely in a recording cha
目的 Tyrosine kinase inhibitors(TKIs)targeting the epidermal growth factor receptor(EGFR)have shown promising clinicalefficacy in non-squamous non-small cell lung cancer(NSCLC)； however,resistance is fr
目的 Through the description of a case and the literature review,we summarized the clinical features,the examination methods,the effetive treatment and prognosis.方法 We present a case report of a 45-year