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Objectives The Xuefuzhuyu capsule is used for the treatment of ischaemic heart disease in China.Evidences have demonstrated that Xuefuzhuyu capsule could protect cardiomyocytes from injury induced by ischaemia, but molecular mechanism underlying this protective effect are still unclear.This study was aimed to investigate potential molecular mechanism by which the protective effect might attributed to an anti-apoptotic effect of Xuefuzhuyu capsule involved in SIRT1 signal transduction pathway using rat myocardial ischaemia injury model.