Balance the risk and benefit of NSAIDs for inflammatory diseases Focus on cardiovascular system

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History Sumerian period: willow leaves by Assyrians Greek: willow bark by Hippocrates St Kevin of Glendalough In 18th century: Reverend Edmund Stone, t763: willow bark-anti-inflammation Treat fever in a malaria patient MacLagan, first clinical trial of willow bark In 19th century: Johann Buchner: extract salicin from willow bark.
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