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Introduction: Mechanical stress plays a key role in periodontal ligament matrix turnover in tooth movement.Matrix metalloproteinase (MMP)-1 which digests a wide variety of extracellular matrix components regulates tissue remodeling.Shear stress which produced by interstitial fluid squeezing around the periodontal ligament (PDL)cells during tooth movement is also an important mechanical stress.Whether shear stress regulates MMP-1 expression and the mechanism have not been clarified.