【摘 要】
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PH-responsive hyperbranched polymers have attracted much attention due to their unique properties for tumor-targeted drug delivery.In this study, we describe a pH-responsive drug carrier, poly (ethyle
【机 构】
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Department of Oral & Maxillofacial-Head Neck Oncology,Shanghai Ninth People's Hospital Affiliated S
【出 处】
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11th Asian Congress on Oeal and Maxillofacial Surgery(第十一届亚洲
论文部分内容阅读
PH-responsive hyperbranched polymers have attracted much attention due to their unique properties for tumor-targeted drug delivery.In this study, we describe a pH-responsive drug carrier, poly (ethylene glycol) (PEG)-hyperbranched polyacylhydrazone (HPAH), which can form nanoscale micelles to be used as anti-cancer drug carriers with pHcontrolled drug release.The molecular structure of PEG-HPAH was confirmed by nuclear magnetic resonance spectroscopy (NMR) and Fourier transform infrared spectroscopy (FTIR).The drug-loaded micelles with a diameter of approximately 190 nm, were prepared using a dialysis method against PBS with a pH of 8.0.The drug-loaded micelles showed the desired pH-dependent drug release properties.
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