【摘 要】
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The inbred DA (Dark Agouti) rats are very susceptible to induced arthritis,especially to pristane induced arthritis (PIA),the attack rate almost reaching 100%.PIA is extremely resembled rheumatoid art
【机 构】
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Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Medicine, Xi'an
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
The inbred DA (Dark Agouti) rats are very susceptible to induced arthritis,especially to pristane induced arthritis (PIA),the attack rate almost reaching 100%.PIA is extremely resembled rheumatoid arthritis (RA) in clinical manifestation or in laboratory diadynamic criteria,so it is optima model to study RA.The inbred E3 rats are wide used for its resistant to PIA completely.The inbred DA.1U rats contains the whole DA non-MHC genes excepted MHC genes,since it is a recombinant inbred of DA and E3 rats,any phenotypic differences in crosses between them will stem from MHC haploid complexes.In addition,it is well known that neuropeptides,such as substance P (SP),somatostatin (SOM),and so on,play an important role in RA.
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