【摘 要】
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Objective: The size and specific shape of bone grafts are important for reconstruction of large mandibular defects.We wanted to repair large mandibular defects using bone engineered with allogenic man
【机 构】
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Chinese PLA Medical School 28 Fu Xing Road,Beijing China 100853
【出 处】
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11th Asian Congress on Oeal and Maxillofacial Surgery(第十一届亚洲
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Objective: The size and specific shape of bone grafts are important for reconstruction of large mandibular defects.We wanted to repair large mandibular defects using bone engineered with allogenic mandibular scaffolds and autologous mesenchymal stem cells (MSCs).Methods: Eighteen beagle dogs received 30-mm bone surgical defects in each left body of the mandible.Beagles were divided into two equal groups.Bony defects of the control group were reconstructed using allograft only.Those of the experimental group were reconstructed using allogenic mandibular scaffold-loaded autologous MSCs.Beagles from each group were killed 4, 12, 24 or 48 weeks after surgery.CT and histological analyses were used to evaluate defect reconstruction.
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