【摘 要】
：
Transient receptor potential (TRP) channels function as cellular sensors to perceive and respond to a variety of environmental stimuli including temperature
【机 构】
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School of Biomedical Sciences
【出 处】
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International Conference for Physiological Sciences 2012(201
论文部分内容阅读
Transient receptor potential (TRP) channels function as cellular sensors to perceive and respond to a variety of environmental stimuli including temperature, pain, pressure and fluid flow.These channels can be divided into seven subfamilies, including TRPV, TRPC, TRPP, and four others.Functional TRP channels are tetrameric complexes consisting of four pore-forming subunits, which could be identical (homotetrameric channels) or different (heterotetrameric channels).In the present study, we found that TRPV4,-C 1, and-P2 associate together to form a physical complex.In function study, this TRPV4-C 1-P2 complex mediates flow-induced Ca2+ influx in HEK293 cells over-expressing TRPV4,-C 1, and-P2 and in rat mesenteric artery endothelial cells (MAECs).
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Zeng Qiang, what people also? How could he be four times with the APEC meeting? He