【摘 要】
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A comparative proteomic analysis using two-dimensional gel electrophoresis (2D-GE) and MALDITof-Tof MS, followed by analysis of the differentially expressed proteins was used to propose a mechanism un
【机 构】
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School of Biosciences, Taylor's University, Universiti Tunku Abdul Rahman Malaysia
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A comparative proteomic analysis using two-dimensional gel electrophoresis (2D-GE) and MALDITof-Tof MS, followed by analysis of the differentially expressed proteins was used to propose a mechanism underlying 2-Methoxy-l,4-Naphthoquinone (MNQ) cytotoxicity.Proteomic analysis on K562 cells upon treatment with MNQ yielded a total of 31 differentially expressed proteins, with 28 being up-regulated and 3 down-regulated.The majority (36%) of the altered proteins were implicated in the antioxidative, stress response and detoxification pathways, which suggested a direct cellular response against the production of intracellular ROS.
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