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吡喹酮治疗细粒棘球蚴病的疗效存在较大争议。本文选用50只小鼠进行药物治疗实验,使之胸、腹腔感染继发性细粒棘球蚴,感染6月后开始,连续灌胃给药,剂量为300ng/kg/日,分别治疗4天、8天、16天、30天和60天后随机处死服药组和对照组小鼠各5只,动态观察小鼠胸、腹腔细粒棘球蚴的形态学变化。实验结果:1.大体:吡喹酮治疗的早期和中期,小鼠胸、腹腔棘球蚴外观基本正常;治疗两月后大部分囊肿张力减低,个别囊塌陷.液体减少。2.光镜:小鼠服药15～30天后,棘球蚴生发层空泡增多,部分生发层的细胞坏死睨落;60天后生发层结构破碎,细胞大多坏死或脱落,广泛空泡化。3.透射电镜:与对
Praziquantel treatment of Echinococcosis is controversial. In this paper, 50 mice were selected for drug treatment experiment, so that the chest, abdominal infection of secondary echinococcus granulosus, started after infection in June, continuous oral administration, the dose of 300ng / kg / day, respectively, for 4 days Five mice were randomly sacrificed at 8 days, 16 days, 30 days and 60 days after treatment. The morphological changes of mouse Echinococcus granulosus were observed dynamically. Experimental results: 1. General: In the early and middle stages of praziquantel treatment, the appearance of mouse thymus and cysticercus cellulosae was basically normal; most of the cyst decreased after two months of treatment, and some of the sacs collapsed. Light microscopy: mouse medication 15 to 30 days, echinococcosis germinal layer vacuoles increased, part of the germinal layer of cell necrosis fall; 60 days after the germinal layer structure is broken, most of the cells necrosis or shedding, a wide range of vacuoles. 3. TEM: And right