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Purpose This study was carried out to analyze the effect of Tumor-infiltrating lymphocytes (TILs),especially regulatory T cells (Tregs),in prognostic value of H CC patients.Methods Tumor-infiltrating lymphocytes (TILs) were analyzed from 57 randomly selected H CC patients.The prognostic effect of groups with high and low numbers was evaluated.Results the increased numbers of FoxP3+ Tregs were found in intratumoral tissue,and for ICOS+FoxP3+Tregs,the increased prevalence in carcinoma was not only in terms of absolute number but also in the percentage in total Foxp3+ cells.Conclusions FoxP3+ Tregs,especially ICOS+FoxP3+ Tregs may contribute to the immunosuppression microenvironment of HCC.