@@ A previous meta-analysis was performed to assess the association between variations in NRAMP l and tuberculosis(TB)risk but its limitations were that it did not report genotype comparative results，and not discuss the association with extra-pulmonary TB(EPTB).So，we carded out an updated meta-analysis to further investigate the association between NRAMP1 and TB susceptibility.searched databases(PUBMED， EMBASE and ISI Web of Knowledge)up to July 2010 using”tuberculosis”‘‘NRAMPl，"SLCllA1"“solute carrier family 11 member l”‘natural resistance-associated macrophage protein 1"，also performed a manual search from relevant original studies.We extracted information on first author,publication year country of origin，age of population，control sources and genotype distribution.Summary ORs and corresponding 95％CIs were estimated by fixed effects or random effects model according to it value.To check for publication bias，a funnel plot，using Eggers linear regression method，Was constructed.