【摘 要】
：
It is estimated that number of mild cognitive impairment (MCI) subjects is 60 million worldwide, and in developed countries where proportion of the elderly is high and increasing, the potential impact
【机 构】
：
Graduate School of Pharmaceutical Sciences Kyoto University
论文部分内容阅读
It is estimated that number of mild cognitive impairment (MCI) subjects is 60 million worldwide, and in developed countries where proportion of the elderly is high and increasing, the potential impact and significance of an early intervention toward those who complain of mild impairment of cognitive function cannot be over-estimated.Among this population, those who satisfy the Petersons criteria for MCI is included.In the process of searching and characterizing for interacting activities with human brain carboxypeptidase B (HBCPB), several CPB-interacting activities was found in cerebrospinal fluid (CSF) and in serum (CPB-BPs).
其他文献
Attention Deficit Disorder (ADD) is a neuro-behavioral developmental syndrome which affects 3-7 percent of school children aged 6-12 years and as many as 10 percent of healthy older children.In the la
Epilepsy(Ep)is one commonly disease of central nervous system,thats pathogenesis is very complicated,and still not clearly.Now numerous evidences support the notion that chronic and repetitive seizure
Neural crest stem cells (NCSC) can differentiate to neurons, glia, melanocytes and smooth muscle cells under stimulation with different growth factors.Transforming growth factor-beta (TGF-β) converts
Multiple Sclerosis is often thought to be an autoimmune disorder, certainly its presence is often accompanied by chronic inflammatory markers.For decades, researchers have observed that pathogens such
Background: Posiphen is in clinical development as an oral treatment for Alzheimers disease (AD).In cell cultures, normal, transgenic and trisomic mice Posiphen reduces the rate of synthesis of amyloi
L-dopa is still, after many years, the central drug in treatment of Parkinsons disease, however many aspects of its actions are still unclear.In early stage Parkinsons disease, L-dopa can improve dopa
According to recent estimates, the majority of work-related upper limb disorders are regarded as diagnostically unclassifiable.However, we have demonstrated in the primary as well as secondary health
Models of human disease have long been used to understand the basic pathophysiology of disease and to facilitate the discovery of new therapeutics.However, as long as models have been used there have
Chemical chaperone therapy is based on a paradoxical molecular phenomenon involving a lysosomal enzyme protein and its competitive inhibitor as intracellular enhancer (chaperone).The mutant enzyme pro
Neurodegeneration and neuronal injury are silent features of initiation of most of neurological diseases.Early diagnosis remains a true difficult task regardless of PET and high resolution nmr imaging