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The neuron population of the hippocampal formation exhibits oscillatory activity within the theta frequency band (4-10 Hz),and the intrinsic resonance properties of individual hippocampal neurons contribute to this network oscillation.The subiculum is the pivotal output region of the hippocampal formation and it is involved in many of the physiological and pathological functions of the limbic system.To study the charactefistcs and underlying mechanisms of resonance activity in subicular pyramidal neurons,we performed whole-cell patch-clamp recordings from these neurons in rat horizontal brain slices.We applied sinusoidal currents with constant amplitudes and linearly increasing frequencies to measure the resonance frequency of subicular pyramidal neurons.We found that the resonance frequency of subicular pyramidal neurons was about 2 Hz at room temperature and 4-6 Hz at 32-35 ℃.