A wide variety of physical movements can be achieved by the human neuromusculoskeletal system,from normal walking to the skillful performance of a professional dancer.All these motor tasks involve the load transmission and distribution through the body,balance and coordination.The quest toward understanding how these tasks are achieved by the human body has been of interest to scientists for centuries.This talk presents our recent attempts to explore the in-vivo working condition and also the mechanical design principle of the human musculoskeletal system during different motor activities.This involves a range of researches into the biomechanics and motor control of human motions at different system levels using an integrated experimental,computational and bio-robotic approaches.Our long term aim is to gain comprehensive understanding of the functions of musculoskeletal systems and the interactions between the musculoskeletal and neuromotor systems.Such research will provide solid scientific foundation for the development of novel preventative and rehabilitative programs and devices,clinical diagnostic and surgical techniques,and also biologically inspired robotics and mechanisms etc.