【摘 要】
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(155/160 words):Mutations in acyl-CoA synthetase long-chain family member 4 (ACSL4),which converts long-chain fatty acids to acyl-CoAs,result in non-syndrom
【机 构】
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KeyLaboratoryforMolecularandDevelopmentalBiology,InstituteofGeneticsandDevelopmentalBiology,ChineseA
论文部分内容阅读
(155/160 words):Mutations in acyl-CoA synthetase long-chain family member 4 (ACSL4),which converts long-chain fatty acids to acyl-CoAs,result in non-syndromic X-linked mental retardation.Using the Drosophila neuromuscular junction (NMJ) as a model,we found that dAcsl,the Drosophila homolog of ACSL4,inhibits synaptic growth by attenuating bone morphogenetic protein (BMP) signaling,a major growth-promoting pathway of NMJ synapses.
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