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The purpose of the present study was to assess the prevalence of metabolic syndrome-related disorders in rural women of Bangladesh.A total of 1535 rural Bangladesh women aged ≥15 years were studied using a population based cross-sectional survey.The prevalence rates of MS were 25.60% (NCEP ATP Ⅲ), 36.68% (modified NCEP ATP Ⅲ), and 19.80% (IDF), as revealed by the present study.Furthermore, based on the NCEP ATP Ⅲ criteria, 11.60% of the subjects were found to have excess waist circumference;29.12% had elevated blood pressure, 30.42% had elevated fasting plasma glucose level, 85.47% had low HDL values and 26.91% had increased triglyceride values.Low plasma HDL level was found to be the most common abnormality in the target population and elevated waist circumference was the least frequent component.Prevalence of MS was more prevalent among postmenopausal women (39.83%) as compared to pre-menopausal (10.20%).Again, MS is associated with impaired angiogenesis where vascular endothelial growth factor (VEGF) plays a key role in angiogenesis through binding to its specific receptor, sVEGF-R1 and sVEGF-R2.VEGF levels were significantly increased in MS subjects (MS vs.non-MS: 575 vs.490, p<0.001).There were no significant relation of sVEGF-R1 and sVEGF-R2 with MS (sVEGF-R1, MS vs.non-MS: 446 vs.667,p=0.093;sVEGF-R2, MS vs.non-MS: 8943 vs.9400, p=0.0.344).In multivariable analyses, we found that VEGF had significant positive associations with fasting blood glucose (r=0.181, p<0.001), BMI (r=0.143, p<0.001), cholesterol (r=0.101, p<0.001), non-HDL cholesterol (r=0.091, p<0.001), LDL cholesterol (r=0.079, p=0.007), insulin(r=0.075, p=0.022), DBP (r=0.064, p=0.025) and SBP (r=0.057, p=0.048) even after adjusting for age.Multiple regression analysis revealed that fasting blood glucose (beta=0.158, p =0.00 1) and BMI (beta =0.083, p =0.017) were independent determinants of VEGF.The present study shows a high prevalence of MS and its associated risk factors in rural Bangladeshi women.These findings are important in that they provide insights that should be helpful in formulating public health policy and in the development of future health prevention strategies in Bangladesh.