【摘 要】
：
A new Simulated Moving Bed (SMB) chromatography concept was developed which was characterized through only four pumps: a feed and an eluent pump for the inlet streams and an extract and a raffinate pu
【机 构】
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Bayer Technology and Engineering (Shanghai) Co., Ltd., Shanghai 201507, China
【出 处】
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第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
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A new Simulated Moving Bed (SMB) chromatography concept was developed which was characterized through only four pumps: a feed and an eluent pump for the inlet streams and an extract and a raffinate pump for the product streams.The 4-pump concept allowed all pumps were located outside of the loop.Therefore, the internal concentration profile was not disturbed, and it led to a higher separation performance.In this work, to exemplify the benefits of the new SMB concept, Ketoprofen racemate separation was studied in detail.Results showed that the purity of the separeated S-Ketoprofen was up to 99.9%, and R-Ketoprofen up to 98.2%.For the separation process, a steady state could be obtained through only 7-8 circles.It was also shown impressively that the SMB productivity was increased significantly while the eluent consumption was decreased.
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