【摘 要】
：
miRNAs have been shown to be dysregulated in many types of hurnan cancer, including breast cancer.In particular,miR-21 was found to be significantly upregul
【机 构】
：
Department of Carcinogenesis The University of Texas M.D.Anderson Cancer Center USA
【出 处】
：
(BITs 3rd Annual World Cancer Congress-2010, Breast Cancer C
论文部分内容阅读
miRNAs have been shown to be dysregulated in many types of hurnan cancer, including breast cancer.In particular,miR-21 was found to be significantly upregulated in several studies of human breast cancer tissues; this dysregulation was also found in ovarian and colorectal cancer.We have used miRNA microarrays from Exiquon to compare expression between normal mouse mammary glands and mouse mammary tumors induced by overexpression ofATF3.RNA from 4 individual tumors was compared to RNA from matched normal mammary glands, and duplicate arrays (3tumors) or a single array (one tumor) were hybridized following the manufacturers protocol.Data was processed with the LIMMA package in BioConductor/R.miRNAs were considered differentially expressed if the adjusted P-value (method of Benjamini and Hochberg) was <5 × 10-4 and expression was altered by at least 2-fold in at least three of the four tumors examined.Using these criteria, 14 up-regulated and 15 down-regulated miRNAs were identified.
其他文献
因为成绩太差,18岁上大二的他被迫离开学校。和大多数被开除学生命运一样,他被社会鄙视。从此一蹶不振吗?不,郭俊峰是个幸运儿,也是个历经挫折而不屈服的人。是3年时间,22岁
随着我国素质教育不断向纵深推进,对学生的美学教育和美育培养引起了越来越多教师的关注.因此,在美术教学中,就需要通过多样化的手段来提升学生的学习兴趣,从而为美学教育做
基于保障变电检修作业安全的目的,围绕检修现场危险点展开论述,提出安全控制的策略,共享给相关人员参考借鉴.根据安全管理实践提出,对环境、设备与工具、工艺运用等,围绕常见
对于身心都处于关键发展阶段的初中生来讲,其认知、价值理念等方面都会受到班主任的影响.因此,为了从整体上提升初中生的综合素养,给学生今后的学习成长奠定坚实基础,班主任
INTRODUCTION: Conventional whole breast radiotherapy reduces in-breast tumor recurrence after lumpectomy for breast cancer.Accelerated, partial breast irrad
在小学数学课堂上,老师是主导,学生是主体,因此师生之间的有效互动显得尤为重要.本文分析了小学数学课堂教学中的有效互动,着眼于有效互动的前提,有效互动的基础,有效互动的
根据新课改的要求,需要教师采取多方面的教学手段帮助学生学习,开创新的教学模式教育理念,将思维导图教学方式融入到教学课堂当中,让学生的课堂充满趣味性,帮助学生更好地理
当今社会我们为人处事都离不开好的交流方式,而幼儿园语言教学是孩子学会交流的有启蒙阶段,让幼儿园阶段的孩子锻炼出较为出色的语言能力,使孩子在启蒙阶段表现出自己的想法
笔者认为,高效教学于计算机学科教师教学领域并不是新课题.但是随着信息时代的到来和信息工具的普及,无论家长、社会等社会各界对新一代人才的计算机专业素养水平要求不断提
截止目前我国氢燃料汽车已达万辆,年车用氢然料电池销量约8000亿,产业规模已见端倪.氢能发电、氢能冶炼、氢家庭热电联供系统、氢医疗、氢保健、氢建筑的逐步兴起,无疑提供几