This paper is concerned with identification and nonlinear predictive control method forMIMO Hammerstein systems with constraints.Firstly,an identification method based on steady-state responses and Sub-model Method is introduced to MIMO Hammerstein system.A modified version of artificial bee colony algorithm is proposed to improve the prediction ability of Hammerstein model.Next,a computationally efficient nonlinear model predictive control algorithm(MGPC)is developed to deal with constrained problem of MIMO system.The identification process and performance of MGPC are shown.Numerical results about a polymerization reactor validate the effectiveness of the proposed method and the comparisons show that MGPC has a better performance than QDMC and basic GPC.