【摘 要】
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This talk describes the metabolite-rich extract of the Australian sponge Plakinastrella clathrata Kirkpatrick,1900and our isolation of over 30 new metabolites from a single(60 g wet weight) specimen o
【机 构】
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School of Chemistry and Molecular Biosciences，The University of Queensland,Brisbane,QLD 4072,Austral
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
This talk describes the metabolite-rich extract of the Australian sponge Plakinastrella clathrata Kirkpatrick,1900and our isolation of over 30 new metabolites from a single(60 g wet weight) specimen of the sponge.1 Structural elucidation of plakortolides(eg.1-4),seco-plakortolides(eg.5),and plakortones(eg.6),including full configurational assignment,was based on extensive spectroscopic and Mosher ester analysis.Diastereomeric sets of plakortolides differed in configuration at C-3/C-4 rather than at C-6,a stereochemical result suggesting a biosynthesis involving cyclization of a 6-hydroperoxydienoic acid intermediate.Isolated seco-plakortolides converted under mild conditions into plakortones with full retention of configuration,enabling us to correct errors in the published literature on plakortolide metabolites.
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