【摘 要】
：
The overall topology and interracial interactions play key roles in understanding structural and functional principles of protein complexes.Elastic network
【机 构】
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苏州大学系统生物学研究中心,苏州215006
【出 处】
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第七届全国生物信息学与系统生物学学术大会
论文部分内容阅读
The overall topology and interracial interactions play key roles in understanding structural and functional principles of protein complexes.Elastic network model (ENM) and Protein contact network (PCN) are two widely used methods for high throughput investigation of structures and interactions within protein complexes.In this work,the comparative analysis of ENM and PCN relative to haemoglobin (Hb) was taken as case study.We examine four types of structural and dynamical paradigms,namely,conformation change between different states of Hbs,modular analysis,allosteric mechanisms studies,and interface characterization of an Hb.The comparative study shows that ENM has advantage in studying dynamical properties and protein-protein interfaces,while PCN is better for describing protein structures quantitatively both from local and global levels.We suggest that the integration of ENM and PCN would give a potential but powerful tool in structural systems biology.
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