【摘 要】
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In last few years,gold revealed more and more unique properties in carbene chemistry.1 Last year,we disclosed that the gold carbenes have an unprecedented c
【机 构】
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华东师范大学化学与分子工程学院,上海
【出 处】
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中国化学会第十三届全国有机合成化学学术研讨会
论文部分内容阅读
In last few years,gold revealed more and more unique properties in carbene chemistry.1 Last year,we disclosed that the gold carbenes have an unprecedented chemo-and site-selectivity and ligand effect toward the functionalization of C-H bond of phenol.2 In order to further understand the origin of this unique transformation,we report a comprehensively combined theoretical and experimental study on the mechanism of the insertion of gold carbenes into the C-H and O-H bonds in phenol.3 It significantly revealed that the ligands have an important effect on the C-H insertion and the reaction proceed through a pathway involving the formation of enolate-like intermediate via the DFT calculations and control experiments.Moreover,this methodology is useful in organic synthesis,late-stage modification of natural products and design of domino reactions.4,5 Recently,we also realized the ortho-selective C-H functionalization of phenols.
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