【摘 要】
：
Platensimycin (PTM) and platencin (PTN),isolated from several strains of Streptomyces platensis,are potent antibiotics against multi-drug resistant bacteria.Rec
【机 构】
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XiangyaInternationalAcademyofTranslationalMedicine,CentralSouthUniversity;HunanEngineeringResearchCe
【出 处】
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第二届中国放线菌生物学与产业化研讨会
论文部分内容阅读
Platensimycin (PTM) and platencin (PTN),isolated from several strains of Streptomyces platensis,are potent antibiotics against multi-drug resistant bacteria.Recently,PTM was also reported to have antidiabetic and antisteatotic effects in mouse models.Through a novel genome-mining method,we have identified six PTM and PTN dual-producing strains.By inactivation of pathway-specific transcriptional repressor gene ptmR1,we then generated three mutant strains which can over-produce PTM or PTN,with a yield of 0.3 g/L by fermentation.
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