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本文采用转篮法配以紫外分光光度法进行了三个厂家六个批号氢氯噻嗪片的体外溶出度的测定,经数据处理求出六个批号的T_(50)、T_d、m等三个参数,经方差分析,六批氢氯噻嗪片的差异高度显著(P<0.01),说明它们体外释放度不一样,因此造成临床疗效不一致,提示进行溶出度测定,作为质量控制标准是很必要的.
In this paper, we measured the in vitro dissolution of six batches of hydrochlorothiazide tablets by rotating basket method and ultraviolet spectrophotometry, and obtained three parameters T_ (50), T_d and m of six lot numbers by data processing, By means of analysis of variance, the differences among the six batches of hydrochlorothiazide tablets were highly significant (P <0.01), indicating that they had different in vitro release efficiencies, leading to inconsistent clinical curative effects, suggesting that dissolution testing should be conducted as a quality control standard.