Notch signaling induced Endothelial mesenchymal transition contribute to unilateral ureteral obstruc

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户：hongmusong

【摘要】

：

Renal fibrosis is the final outcome of all progressive kinds of chronic kidney disease.The aim to explore the mechanism and block the progress of renal fibrosis is always an important field in Nephrol

【作者】

：

Hao Xu Baohua Li Yun Wang

【机构】

：

Department of Cell Biology, Third Military Medical University, Chongqing, 400038, China

【出处】

：

中国细胞生物学学会2015年全国学术大会

【发表日期】

：

2015年4期

【关键词】

：

Notch signaling renal fibrosis EndMT UUO

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Efficient ER exit of Autotaxin is mediated by a di-phenylalanine motif in its C-terminal region

Autotaxin (ATX), also known as ENPP2, is the key enzyme to produce extracellular lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC).

会议

AutotaxinSecretionDi-phenylalanine motifER exitENPP

Selected inhibition by herbicide acetochlor of adrenergic receptor mediated calcium oscillations in

Herbicide acetochlor after application enters both surface and underground waters, so that the equilibrated acetochlor concentrations in rivers and streams could be sufficiently high (in nM) to exert

会议

acetochloradrenergic receptorcalcium oscillationshepatocytes

表观遗传修饰因子TET2维持中枢神经系统中神经元的存活

DNA双加氧酶Ten-Eleven Translocation(TET)是新发现的一类重要的表观遗传修饰因子,其通过将DNA序列中的5-甲基胞嘧啶(5mC)氧化为5-羟甲基胞嘧啶(5hmC),进而调控基因的转录活性.在哺乳动物中,TET家族包括TET1,TET2,TET3.三个成员的羧基段序列含有双加氧酶活性结构域,并且具有高的保守性,而其氨基段序列则差异很大.已有研究报道,TET蛋白在干细胞的干

会议

TET2神经元细胞存活中枢神经系统

Rab5a is required for spindle length control and kinetochore-microtubule attachment during meiosis i

Rab GTPases are highly conserved components of vesicle trafficking pathways.Rab5, as a master regulator of endocytic trafficking, has been shown to function in membrane tethering and docking.

会议

CENPFvesicleschromosome

Kif18A and MCAK cooperatively regulate chromosome congression and alignment in mitosis

The accurate control of spindle microtubes (MTs) dynamics is critical for chromosome congression,alignment and segregation in mitosis.

会议

Kif18AMCAKchromosome congressionmicrotubes (MTs) dynamics

The protected mechanism of LMCTS on anti-myocardial ischemia reperfusion injury of rat

It is well known that low molecular weight chitosan (LMCTS) owns good affinity for human body, which can enhance human immunity, strengthen the anti-aging, inhibit cancer metastasis and improve the li

会议

LMCTSischemia-reperfusion injuryTLR4MyD88NF-κB

LIMK1在瘦素介导的人成骨肉瘤耐细胞增殖、迁移中的作用

目的探讨LIMK1在瘦素介导的人成骨肉瘤耐药细胞增殖、迁移中的作用。方法采用逐步增加药物剂量冲击诱导方法诱导人成骨肉瘤MG63细胞株；采用基因转染、RT-PCR、Western blotting等实验技术检测亲本细胞及耐药细胞中LIMK1及MDR1在mRNA水平和蛋白水平的表达差异；通过CCK8增殖实验、流式细胞仪检测细胞周期、细胞划痕等实验检测了LIMK1在瘦素介导的人成骨肉瘤长春新碱耐药细

会议

LIMK1瘦素骨肉瘤多药耐药基因沉默

KIF11作为一个新的caspase-1靶点嵌合到caspase-1依赖性的细胞死亡

细胞驱动蛋白KIF11能在有丝分裂时期将中心粒分离。抑制KIF11可激活caspase-3而引起细胞凋亡，但其信号通路相关机制尚未知晓。为了弄清这一细胞死亡通路，我们以人胚肾细胞HEK293T和人乳腺肿瘤细胞MDA-MB-231为研究对象，通过脂质体转染dnKIF11-T(dominant negative KIF11-tail)基因片段，抑制内源性KIF11的功能，结果显示dnKIF11-T大量

会议

表皮生长因子KIF11Caspase-1RIPK2细胞死亡

Inhibition of Humanized Antibody cHAb18 On Hepatocellular Carcinoma Cell Motility and Involving Mole

CD147 is highly expressed in tumor tissues and on the membrane of tumor cells.Our previous studies have proved that the interaction of CD147 with integrin can activate the downstream signaling pathway

会议

humanized antibodyCD147hepatocellular carcinomacell motilityGIV/Girdin

Purinergic Signaling Regulates Sperm Chemotaxis Induced by Uterus-derived Factor (UDF) in Nematode A

Directional migration of sperm to oocyte is the prerequisite for successful fertilization.In most animal species, motile sperm are attracted by chemical factors released from oocyte-a process named ch

会议

sperm chemotaxisUDFATPpurinergic signalingAscaris suum

Notch signaling induced Endothelial mesenchymal transition contribute to unilateral ureteral obstruc

与本文相关的学术论文