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  5. Association of cytochrome P450 2C19 G681A polymorphism with high on-treatment platelet reactivity in

Association of cytochrome P450 2C19 G681A polymorphism with high on-treatment platelet reactivity in

来源 :第十二届中国介入心脏病学大会(CIT2014) | 被引量 : 0次 | 上传用户：xiao4869
【摘 要】
：
Background High on-treatment platelet reactivity (HTPR) is associated with a worse prognosis after percutaneous coronary intervention.The mechanisms underlying HTPR are not fully understood.Cytochrome
【作 者】
：
Zhao Qing Liu Huiliang Wei Yujie Lu Jing Han Wei 
【机 构】
：
Department of Cardiology,General Hospital of Chinese People's Armed Police Forces,Beijing 100039,Ch
【出 处】
：
第十二届中国介入心脏病学大会(CIT2014)
【发表日期】
：
2014年3期
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Background High on-treatment platelet reactivity (HTPR) is associated with a worse prognosis after percutaneous coronary intervention.The mechanisms underlying HTPR are not fully understood.Cytochrome P450 2C19 (CYP2C19) plays an important role in clopidogrel biotransformation to its active form,because of the high frequency of CYP2C 19 G681A polymorphism in Asian population.We aimed to elucidate the preliminary association of cytochrom P450 2C19 G681A polymorphism with HTPR.
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