【摘 要】
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Upconverting nanoparticles(UCNPs)present a new technology for optical imaging/detection which is a growing field with both diagnostic and drug discovery use
【机 构】
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Departmentofchemistry,FudanUniversity,Shanghai200433,China
【出 处】
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第九届全国微全分析系统学术会议、第四届全国微纳尺度生物分离分析学术会议、2014国际微流控芯片与微纳尺度生物分离分析学术
论文部分内容阅读
Upconverting nanoparticles(UCNPs)present a new technology for optical imaging/detection which is a growing field with both diagnostic and drug discovery uses.Currently,fluorophores including fluorescent dyes/proteins and quantum dots(QDs)are used for fluorescence-based imaging and detection.These are based on downconversion fluorescence,emitting low energy fluorescence when excited by high energy light(such as UV or short wavelength visible light).Fluorophores in current use have several drawbacks: photobleaching,autofluorescence,short tissue penetration depth and tissue photo-damage.UCNPs emit detectable photons of higher energy in the visible range upon irradiation with near-infrared(NIR)light based on a process termed upconversion.UCNPs show absolute photostability,negligible autofluorescence,high penetration depth and minimum photodamage to biological tissues.They can be used for ultrasensitive interference-free biodetection because most biomolecules do not have upconversion properties.
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