Iron is a indispensable element for all living cells,and though essential for life,it would be toxic when it saturates the natural buffering mechanism.So far,utilizing iron chelators for therapeutic application is one of the most classical approaches and has caused extensive attention.In fact,3-hydroxypyridin-4-ones are one of the main candidates of orally active iron chelating alternatives.The objective of our research is to synthesize the methyl substituted 3-hydroxypyridin-4-ones at different vacant positions and investigate the corresponding pKa and iron affinity constant.