Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：zhangwenda_gz

【摘要】

：

【作者】

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Zhiqiang Pan Ming Zhang Tao Ma Zhou-Ya Xue Jun-Li Cao

【机构】

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Jiangsu Province Key Laboratory of Anesthesiology,Jiangsu Province Key Laboratory of Anesthesiaand A

【出处】

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2016年国际生理学学术大会

【发表日期】

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2016年6期

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　　DNA 5-hydroxylmethylcytosine(5hmC)catalyzed by ten-eleven translocation methylcytosine dioxygenase(TET)occurs abundantly in neurons of mammals.However,the in vivo causal link between TET dysregulation and nociceptive modulation has not been established.Here,we found that spinal TET1 and TET3 were significantly increased in the model of formalin-induced acute inflammatory pain,which was accompanied with the augment of genome-wide 5hmC content in spinal cord.

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Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2

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