A 'conditional-on' mouse model of fibrosyplasia ossificans progressiva (FOP)

来源 :第七届国际骨质疏松及骨矿盐疾病学术会议 | 被引量 : 0次 | 上传用户:vincent_iong
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Background: FOP (MIM 135100) is an autosomal dominant disorder characterized by early onset, episodic and progressive ossification of skeletal muscle and connective tissue.FOP is driven by mutations in the intracellular domain of ACVR1, the most common mutation being Arg206His (R206H).
其他文献
Purpose To study the cost of osteoporotic fracture inChinaand, thus, to provide essential information about the burden of this disease to individuals and society.Methods This prospective observational
会议
目的 通过比较外侧钢板与抗滑钢板在治疗老年性旋后外旋型三踝骨折的手术效果的差异.方法 回顾性分析了在2009年1月至2011年12月期间31例符合标准的旋后外旋型三踝骨折手术治疗的资料,男性13例,女性18例,年龄为65 ~ 85岁,平均年龄69.8岁.患者按照人院时病历号码的尾号,奇数号码组选用抗滑钢板即实验组,偶数号码组选用外侧钢板即对照组,结果实验组8名男性,11名女性,对照组5名男性,7名
会议
目的 假体周围骨溶解,假体松动是人工关节置换后影响假体长期使用的主要原因.假体表面释放的磨损颗粒诱导破骨细胞过度活化在整个病理过程中起着关键性作用.特异性抑制破骨细胞的过度活化及其骨吸收功能是预防假体松动的理想办法.依诺沙星作为一种抗生素,除具有广谱的抗菌作用,我们还发现它对破骨细胞具有强大的抑制作用.
会议
Background: Vitamin D deficiency becomes very common and has been associated with a various type of disorders.So far little is known about vitamin D status in Chinese.The aim of this study was to inve
会议
Background: Vitamin D insufficiency and deficiency is pandemic in the world, while its threshold of optimal range was controversial.The lack of sunshine exposure is a common cause of vitamin D deficie
会议
Background: Vitamin D deficiency is documented as a common health problem in the world.Limited data has been found on the prevalence of vitamin D deficiency in Beijing area.
会议
Background:To evaluate the feasibility of routine bone biopsy during percutaneous kyphoplasty (PKP) for vertebral compression fractures (VCF).Methods:A retrospectively maintained database of 93 patien
会议
Background: Osteoporosis is a major public health problem characterized by low bone mineral density (BMD).Genetic factors play important roles in determining population variation of BMD.Genome-wide as
会议
Background: To clarify the therapeutic mechanism of Liuwei Dihuang Pills (LDP) treatment postmenopausal osteoporosis (PMO) with kidney YIN deficiency.Methods: Microarray was used to identify the diffe
会议
Background: Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is an autosomal recessive disorder caused by mutations in the CLDN 16 or CLDN 19 genes, encoding claudin-16 and cla
会议