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目的:研究灯盏花乙素苷元对大鼠实验性脑缺血的保护作用。方法:灯盏花乙素苷元(100,50,25 mg.kg-1)给大鼠连续灌胃7 d,采用电凝法阻断大鼠大脑中动脉(MCAO)制备局部脑缺血模型,缺血24 h后测定神经行为学评分和脑梗死面积;采用结扎双侧颈总动脉致全脑缺血模型,观测脑组织病理改变、脑含水量和脑组织中Na+,K+含量;实验同时设灯盏花乙素(100 mg.kg-1)阳性对照。结果:灯盏花乙素苷元能够明显改善MCAO局部脑缺血大鼠的神经功能障碍,缩小脑梗死面积;降低全脑缺血大鼠的脑含水量,抑制缺血脑组织的Na+潴留及K+流失现象,并可改善光镜下脑组织缺血性损伤。结论:灯盏花乙素苷元对大鼠实验性脑缺血模型具有保护作用,疗效优于灯盏花乙素。
Objective: To study the protective effect of scutellarin on experimental cerebral ischemia in rats. Methods: Erigeron saponins (100, 50, 25 mg.kg-1) were given intragastrically for 7 days. Electro-coagulation was used to block the cerebral ischemia model of middle cerebral artery (MCAO) Neurobehavioral scores and infarct size were measured 24 h after ischemia. Whole brain ischemia models were induced by ligation of bilateral common carotid arteries. The pathological changes, brain water content and contents of Na + and K + in brain tissue were observed. At the same time, Scutellarin (100 mg.kg-1) positive control. Results: Erigeron could significantly improve neurological dysfunction, reduce infarct size in MCAO rats, decrease cerebral water content in rats with global cerebral ischemia, inhibit Na + retention in ischemic brain and K + Loss phenomenon, and can improve brain tissue ischemic injury under light microscope. Conclusion: The scutellarin has a protective effect on experimental cerebral ischemia model in rats, and the curative effect is better than that of scutellarin.