论文部分内容阅读
Many reported aptamers are G-rich oligonucleotides(GROs),which bind their targets based on the G-quadruplex structures.
The Antitumor Activity of G-Quadruplex Aptamer AS1411 Encapsulated by Nucleobase Lipid DNCA
【摘 要】
：
Many reported aptamers are G-rich oligonucleotides(GROs),which bind their targets based on the G-quadruplex structures.
【机 构】
：
State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking Univer
【出 处】
：
中国化学会第十届全国化学生物学学术会议
【发表日期】
：
2017年10期
其他文献
Drug-resistant bacteria pose an urgent public-health crisis.Over the years,β-lactams were the antibiotics of choice for treatment of S.aureus infections1.
β-Lactam antibiotics are widely used in the treatment of bacterial infections.However,The overuse of antibiotics leads to the emergence of drug-resistant bacteria,which has posed a great threat to hum
The drug-resistant bacteria have been a serious threat to the clinical treatment.These bacteria hydrolyze almost all β-lactam antibiotics by expressing the metallo-β-lactamses(MβLs).
The facile dissemination of genes encoding β-lactamase,enzymes capable of hydrolyzing β-lactms,is the important mechanism in antibiotic resistance.
The appearance of antibiotic resistance caused by metallo-β-lactamases(MβLs)is a global public health threat due to their rapid spread.
Non-alcoholic fatty liver disease(NAFLD)is the hepatic manifestation of obesity and metabolic syndrome,which encompasses a histological spectrum ranging from simple steatosis to nonalcoholic steatohep
Protective effects of Arbutin against Rotenone-induced oxidative stress through AMPK-autophagy relat
Arbutin(Arb),a natural polyphenol extracted from various medicinal plants,shows significant antioxidant activity.
Aminoacyl-tRNA synthetases(aaRSs)catalyze the ligation of amino acids to cognate tRNAs.
会议
By using β-glucuronidase enzyme,microbiota in gastrointestinal(GI)scavenge sugar from glucuronidated compounds as a source of carbon,resulting in activation of drugs from its non-toxic form to toxic c
Phenazine-1-carboxylic acid(PCA)as a natural product widely exists in microbial metabolites of Pseudomonads and Streptomycetes and has been registered for the fungicide against rice sheath blight in C