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5. Over-expression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of

Over-expression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of

来源 :中国药理学会北美分会药理学学术大会 | 被引量 : 0次 | 上传用户：chanQ

【摘 要】

：

The resistance mechanisms that limit the efficacy of retinoid therapy in cancer are poorly understood.Sphingosine kinase 2(SphK2)is a highly conserved enzyme that is mainly located in the nucleus and

【作 者】

：

Wen-na SHI Shu-xiang CUI Zhi-yu SONG Shu-qing WANG Shi-yue SUN Xin-fengYU Yu-hang ZHANG Zu-hua GAO Xian-jun QU 

【机 构】

：

Department of Pharmacology,School of Basic Medical Sciences,Capital Medical University,Beijing,China

【出 处】

：

中国药理学会北美分会药理学学术大会

【发表日期】

：

2017年10期

【关键词】

：

sphingosine kinase 2 (SphK2) retinoid therapy resistance cytoplasmic RXRα polyub 

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　　The resistance mechanisms that limit the efficacy of retinoid therapy in cancer are poorly understood.Sphingosine kinase 2(SphK2)is a highly conserved enzyme that is mainly located in the nucleus and endoplasmic reticulum.

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