【摘 要】
：
目的：全面了解Matrilysin在胃癌组织中的表达情况,分析其与胃癌侵袭、转移和预后的相关性.方法：以52例胃癌患者为研究对象,分别应用RT-PCR、Western blot及免疫组织化学方法检测Matrilysin在胃原发癌、胃正常黏膜及淋巴结转移癌组织中的表达,对所有病例进行随访,分析Matrilysin与胃癌侵袭、转移和预后的相关性.结果：Matrilysin在胃原发癌和淋巴结转移癌组织中
【机 构】
：
中国医科大学附属第一医院,胃肠肿瘤外科,沈阳,110001
【出 处】
：
第9届全国胃癌学术会议暨第二届阳光长城肿瘤学术会议
论文部分内容阅读
目的：全面了解Matrilysin在胃癌组织中的表达情况,分析其与胃癌侵袭、转移和预后的相关性.方法：以52例胃癌患者为研究对象,分别应用RT-PCR、Western blot及免疫组织化学方法检测Matrilysin在胃原发癌、胃正常黏膜及淋巴结转移癌组织中的表达,对所有病例进行随访,分析Matrilysin与胃癌侵袭、转移和预后的相关性.结果：Matrilysin在胃原发癌和淋巴结转移癌组织中表达明显增高,而在胃正常黏膜组织中表达较弱或缺失,差异有统计学意义(P＜0.05)；其mRNA和蛋白质表达水平具有较高的一致性(P＜0.001).Matrilysin表达在胃原发癌为浸润型癌、癌侵透浆膜、浆膜受侵面积＞20cm2、淋巴结分期晚者(N3)中明显增高(P＜0.001).Matrilysin高表达组患者5年生存率为34.1％,而Matrilysin低表达组为55.6％,差异有统计学意义(X2=9.778,P=0.002)结论：Matrilysin基因表达与胃癌的侵袭、转移和预后有关,是反映胃癌恶性生物学行为较好的分子指标.
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