【摘 要】
：
Background After autologous saphenous veins grafted into arterial circulation via aortocoronary bypass surgery, the lumen of grafted veins is narrowed because of smooth muscle cells excessive hyperpla
【出 处】
：
第17届中国南方国际心血管病学术会议
论文部分内容阅读
Background After autologous saphenous veins grafted into arterial circulation via aortocoronary bypass surgery, the lumen of grafted veins is narrowed because of smooth muscle cells excessive hyperplasia.Recently, evidence indicates that stromal cell derived factor-1α (SDF-1α) is involved in the process of neointimal hyperplasia via recruiting circulating SMC progenitor cells after wire-induced arterial injury.The goal of this study is to investigate the expression of SDF-1α and SMC progenitor cells in neointimal hyperplasia in vein graft model.Sca-1+/SMMHC+
其他文献
Aims The insulin-PI3K-mTOR pathway exhibits a variety of cardiovascular activities including protection against I/R injury.Lin28aenhanced glucose uptake and insulin-sensitivity via insulin-PI3K-mTOR s
目的 探究MCT-induced-PAH大鼠的死亡原因及可能的应对策略;方法 雄性SD大鼠,随机分为对照组20只(A),模型组60只(B),死亡组(C,死亡大鼠),腹腔注射野百合碱50mg/kg诱导PAH模型,观察记录动物习性改变,8周后计算死亡率,测量体重、右室压力,右室肥厚指数,肺小微动脉管壁肥厚指数及炎症浸润.用万方、维普、知网、百度学术数据库,设定检索词和纳入和排除标准,对模型分布、死亡率
目的 快激活延迟整流钾电流(Ikr)是心肌细胞动作电位复极的重要电流,心肌α1和β1肾上腺素受体分别激活后均可影响Ikr电流大小,探讨预先激活α1肾上腺素受体后对β1肾上腺素受体调控心肌Ikr电流的影响.方法 制备豚鼠心肌细胞,将细胞分为三组,空白对照组,苯肾上腺素组(用α1肾上腺素受体激动剂phenylephrine预处理细胞),PDBu组(用蛋白激酶C激活剂PDBu预处理细胞);然后分别用β1
目的 观察养心通脉部位方(active principle region of Yangxing Tongmai Formula,apr-YTF)对大鼠骨髓间充质干细胞(mesemchymal stem cells,MSCs)体外诱导其分化为心肌样细胞的作用.方法 采用骨髓细胞体外培养技术分离大鼠MSCs,以流式细胞仪检测细胞表面标志;采用四甲基偶氮唑盐(MTT)法观察apr-YTF对MSCs增殖
目的 构建特异性针对人血管内皮生长因子(VEGFA)mRNA基因的siRNA表达的慢病毒载体,并测定其对VEGFA基因的沉默率,验证沉默率较高的干扰序列.方法 设计2种特异性针对人VEGFA基因的发夹样siRNA(KD1,KD2),分别连接入pGCSIL-GFP载体,转化扩增后得到重组载体pGCSIL-GFP-siVEGFA.将重组载体与pHelper 1.0和pHelper 2.0通过Lipof
Introduction Endothelium dysfunction plays a critical role in atherosclerosis.MicroRNAs are endogenous non-coding RNAs that suppress gene expression by binding to the 3 untranslated regions of target
Objective It is well know that epigenetic plays an important role in controlling the regulation of gene expression during biological development.Troponin I is one of regulatory myofibril protein in he
Bacground Cellular repressor of E1A-stimulated genes (CREG) is a lysosomal glycoprotein implicated in maintaining vascular homeostasis.However, the specific roles and the molecular mechanisms underlyi
Background Cellular repressor of E1A-stimulated genes (CREG), a lysosomal glycoprotein implicated in cellular growth and differentiation, has been proposed be a new cardiovascular homeostasis regulato
Background We hypothesized that mesenchymal stem cells (MSCs) overexpressing Cellular Repressor of E1A-stimulated Genes (CREG) showed improved survival and engraftment in the infarcted heart and promo