Metabotropic glutamate receptors of class C GPCRs exist as constitutive dimers,which play important roles in activating excitatory synapses of the central nerve system.However,due to lack of crystal s
The tetrameric influenza B M2 channel(BM2),an acid activated proton channel,is important in the influenza virus B lifecycle.A conserved HxxxW motif is responsible for proton conduction and channel gat
Cellular membranes are mainly composed of the lipid bilayer.Accurate description of lipid-protein and lipid-drug-like-molecule interactions,which occur in the context of membrane,is crucial to study p
Alzheimers disease is associated with overactivity of butyrylcholinesterase(BChE),a nonspecific enzyme with clinical pharmacological and toxicological significance,which hydrolyzes the neurotransmitte
O-linked β-N-acetyl-D-glucosamine(O-GlcNAc) transferase(OGT) is an essential enzyme in many cellular physiological catalytic reactions that regulates protein O-GlcNAcylation [1].Aberrant glycosylation