A fragment activity assay reveals the key residues of TBC1D15 GTPase-activating protein(GAP)in Chilo

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户:shyan
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  GTPase-activating proteins(GAPs)with a TBC(Tre-2/Bub2/Cdc16)domain architecture serve as negative regulators of Rab GTPases.Here,we analyzed the Rab-GAP specificity of TBC1D15 in the evolution and influence of key amino acid residue mutations on Rab-GAP activity.
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