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目的：以胶原诱导关节炎(CIA)大鼠为模型，观察二甲双胍对CIA大鼠血清细胞因子、脾脏辅助性T细胞17 (TH17)及调节性T细胞(Treg)分化的影响和脾脏AMPK、mTOR的表达，初步探讨二甲双胍治疗类风湿关节炎的可能机制。
二甲双胍治疗胶原诱导关节炎大鼠的作用及机制探索
【摘 要】
：
目的：以胶原诱导关节炎(CIA)大鼠为模型，观察二甲双胍对CIA大鼠血清细胞因子、脾脏辅助性T细胞17 (TH17)及调节性T细胞(Treg)分化的影响和脾脏AMPK、mTOR的表达，初步探讨二甲双胍治疗类风湿关节炎的可能机制。
【机 构】
：
嘉兴市第一医院11A病区风湿免疫科
【出 处】
：
浙江省免疫学会第十次学术大会
【发表日期】
：
2016年8期
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