【摘 要】
：
Accumulation of amyloid-β (Aβ) peptide is a pathological hallmark of Alzheimers disease (AD).Reduction of Aβ is believed to be a promising approach for t
【机 构】
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Neurodegeneration Research GlaxoSmithKline R&D China
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Accumulation of amyloid-β (Aβ) peptide is a pathological hallmark of Alzheimers disease (AD).Reduction of Aβ is believed to be a promising approach for the treatment ofAD.Aβ is generated by the proteolytic cleavage of amyloid precursor protein (APP) by β-and β-secretases.Two classes of therapeutic agents are under development for the reduction of Aβ through β-secretases:β-secretases inhibitors (GSI) and B-secretases modulators (GSM).
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