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Purpose:Glaucoma is one of the leading causes of blindness all around the world.The optic nerve degeneration it causes is irreversible.The research on induced pluripotent stem (iPS) cells brings new hope to regenerative medicine.However,virus genome integration into the host cells is one of the major obstacles that hinder the clinical use of iPS cells.This study aims to generate glaucoma patient-specific iPS cells by using non-virus integration-free vectors.