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Hand-foot-and-mouth disease(HFMD) is a major health concern in China and other Asia Pacific regions.In mainland China,over 3000 fetal cases caused by HFMD have been reported since 2008.No vaccine or drugs is available yet.The causative agents responsible for HFMD include human enterovirus 71(EV71),coxsackievirus A16(CVA16),coxsackievirus A6 and other viruses.