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<正>Glioblastoma multiforme(GBM),the most common malignant brain cancer in humans,is characterized by high proliferation rates,extensive single-cell infiltration into the adjacent and distant brain parenchyma,and robust neoangiogenesis,which together inevitably confer resistance to current treatment modalities.Co-ordinated genomic analyses of large cohorts of clinical GBM specimens rank PDGFRαthird among the top 11 amplified genes in