Curcumin is a natural yellow pigment,product from turmeric (Curcuma longa Linn.),it has a lot of physiological activities such as antioxidation,anti-inflammation,hepatoprotection,etc.Pancreatic exocrine cell line-AR42J can be transdifferentiated to hepatocytes by exposing to dexamethasone,oncostatin M and insulin.In this study,we would like to establish a hepatoprotective screening model and investigate hepatotoxicity from CCl4 on AR42J.