Pattern classification,the core theory in Chinese medicine clinical practice,will be a complementary method to classify individuals status and contribute to personalized medicine.The author provided a logical argument focuses on the innovation that may result from integrated pattern classification and biomedical diagnosis,and introduced some novel research design and methods of pattern classification researches using systemic biological approaches and evidence-based medicine design,as well as developed novel approaches on the methodology of clinical effectiveness evaluation on Chinese medicine and new drug research and development.