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  5. Rapamycin regulates the expression of Krüppel-like transcription factor 2 through nonphosphorylates

Rapamycin regulates the expression of Krüppel-like transcription factor 2 through nonphosphorylates

来源 :第11届中国介入心脏病学大会 | 被引量 : 0次 | 上传用户：suka
【摘 要】
：
Background Previous studies identified KLF2 as a key "molecular switch" that regulated the expression of TF, and eNOS.And we built on these initial observations and provided evidence that rapamycin in
【作 者】
：
MA Qian YU Miao YANG Shi-wei JIA Dean ZHOU Yu-jie 
【机 构】
：
Lung and Blood Vessel Diseases,Capital Medical University Affiliated Beijing Anzhen Hospital and Bei
【出 处】
：
第11届中国介入心脏病学大会
【发表日期】
：
2013年7期
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Background Previous studies identified KLF2 as a key "molecular switch" that regulated the expression of TF, and eNOS.And we built on these initial observations and provided evidence that rapamycin induced the expression of KLF2in human umbilical vein endothelial cells (HUVECs).PI (3, 4, 5) P3 mediates activation of protein kinase B, which phosphorylates and inactivates Foxos, thereby terminating expression of KLF2 and its target genes.We hypothesized that rapamycin might induce the expression and activity of KLF2 through nonphosphorylates and activates Foxos.
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