论文部分内容阅读
Study Objectives:Toinvestigatechangesinregionalcerebralbloodflow(rCBF)inawakepeoplewithuntreatedsevere obstructivesleepapneapatients(OSAs)comparedwithgoodsleepers(GSs). Design:Arterialspinlabelingperfusionimagingtoquantifycerebralperfusionbasedonresting-statefunctionalmagnetic resonanceimaging(MRI).Lyingsupineina3.0-Tmagneticresonanceimagingscannerinthenight.30subjectswithOSA(males; meanage38.4y,range25-55)and30controls(males;meanage:38.3y,range26-52)matchedforageandyearsofeducation wereincludedinthisstudy. Results:ComparedwithGSs,participantswithsevereOSAhadreducedrCBFintheleftcerebellumposteriorlobe,lefttemporal lobe,rightmedialfrontalgyrus,bilateralparahippocampalgyrus,andhigherrCBFinthebilateralsuperiorfrontalgyrus.Thelower meanCBFintherightparahippocampalgyrusshowedasignificantpositivecorrelationwitharousalindex(r=0.365,P=0.047).The highermeanCBFintheleftsuperiorfrontalgyrusshowedasignificantpositivecorrelationwithlongestapneatime(r=0.422, P=0.020),andintherightsuperiorfrontalgyrusshowedasignificantpositivecorrelationwithlongestapneatime(r=0.447, P=0.013). Conclusions:OurresultsshowthealteredrCBFpatterninleftcerebellumposteriorlobe,lefttemporallobe,leftmedialfrontal gyrus,bilateralparahippocampalgyruandsuperiorfrontalgyrusinpatientswithsevereOSA.Thearterialspinlabelingperfusion imagingmethodisausefulnoninvasiveimagingtoolfordetec-tionofearlychangesinregionalcerebralbloodflowinpatients withOSA.