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More than 4500 years agoin the ancient predynastic China,Emperor Shennong discovered and evaluated several herbs with medicinal properties.One of them was mushroom Ganoderma lucidum(Lingzhi,Reishi),which showed "stimulating properties".G.lucidum was one of the must valuable medicinal mushrooms described in the first Chinese pharmacopoeia and used in Traditional Chinese medicine(TCM).Modern molecular biology methods together with animal experiments helped to understand the mechanisms of healing activities of this ancient mushroom.For example,several extracts or purified compound from G.lucidum,targeted specific hallmarks of cancer including sustained proliferative signaling,resistance to apoptosis,tumor promoting inflammation,induction of angiogenesis and activation of invasion and metastasis.